Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4370281..4370900 Replicon chromosome
Accession NZ_OW849470
Organism Klebsiella oxytoca isolate 325

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag LQ213_RS20550 Protein ID WP_004099646.1
Coordinates 4370682..4370900 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ213_RS20545 Protein ID WP_004099648.1
Coordinates 4370281..4370655 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ213_RS20535 (AI2699V1_4001) 4365437..4366630 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ213_RS20540 (AI2699V1_4002) 4366653..4369799 + 3147 WP_064371881.1 multidrug efflux RND transporter permease subunit AcrB -
LQ213_RS20545 (AI2699V1_4003) 4370281..4370655 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
LQ213_RS20550 (AI2699V1_4004) 4370682..4370900 + 219 WP_004099646.1 HHA domain-containing protein Toxin
LQ213_RS20555 (AI2699V1_4005) 4371061..4371627 + 567 WP_004099644.1 maltose O-acetyltransferase -
LQ213_RS20560 4371596..4371733 - 138 WP_227629809.1 hypothetical protein -
LQ213_RS20565 (AI2699V1_4006) 4371764..4372234 + 471 WP_004111038.1 YlaC family protein -
LQ213_RS20570 (AI2699V1_4007) 4372209..4373663 - 1455 WP_064371883.1 PLP-dependent aminotransferase family protein -
LQ213_RS20575 (AI2699V1_4008) 4373766..4374464 + 699 WP_064371884.1 GNAT family protein -
LQ213_RS20580 (AI2699V1_4009) 4374461..4374601 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ213_RS20585 (AI2699V1_4010) 4374601..4374864 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T295709 WP_004099646.1 NZ_OW849470:4370682-4370900 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT295709 WP_004099648.1 NZ_OW849470:4370281-4370655 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References