295704

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 886758..887415 Replicon chromosome
Accession NZ_OW849470
Organism Klebsiella oxytoca isolate 325

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag LQ213_RS04240 Protein ID WP_004105559.1
Coordinates 887005..887415 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag LQ213_RS04235 Protein ID WP_004105561.1
Coordinates 886758..887024 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ213_RS04210 (AI2699V1_0821) 881937..883370 - 1434 WP_064372034.1 6-phospho-beta-glucosidase -
LQ213_RS04215 (AI2699V1_0822) 883491..884219 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
LQ213_RS04220 (AI2699V1_0823) 884270..884581 + 312 WP_064372033.1 N(4)-acetylcytidine aminohydrolase -
LQ213_RS04225 (AI2699V1_0824) 884743..885402 + 660 WP_004105569.1 hemolysin III family protein -
LQ213_RS04230 (AI2699V1_0825) 885531..886514 - 984 WP_064372032.1 tRNA-modifying protein YgfZ -
LQ213_RS04235 (AI2699V1_0827) 886758..887024 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
LQ213_RS04240 (AI2699V1_0828) 887005..887415 + 411 WP_004105559.1 protein YgfX Toxin
LQ213_RS04245 (AI2699V1_0829) 887424..887945 - 522 WP_004105557.1 flavodoxin FldB -
LQ213_RS04250 (AI2699V1_0830) 888067..888963 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
LQ213_RS04255 (AI2699V1_0831) 888986..889699 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ213_RS04260 (AI2699V1_0832) 889705..891438 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T295704 WP_004105559.1 NZ_OW849470:887005-887415 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT295704 WP_004105561.1 NZ_OW849470:886758-887024 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References