Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 669878..670470 Replicon chromosome
Accession NZ_OW849470
Organism Klebsiella oxytoca isolate 325

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LQ213_RS03205 Protein ID WP_016808034.1
Coordinates 670096..670470 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag LQ213_RS03200 Protein ID WP_004105957.1
Coordinates 669878..670099 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ213_RS03180 (AI2699V1_0619) 665439..665993 + 555 WP_004105965.1 YgjV family protein -
LQ213_RS03185 (AI2699V1_0620) 666008..667255 - 1248 WP_004105963.1 serine/threonine transporter SstT -
LQ213_RS03190 (AI2699V1_0621) 667510..668478 - 969 WP_004105962.1 TerC family protein -
LQ213_RS03195 (AI2699V1_0622) 668729..669718 - 990 WP_204724101.1 Gfo/Idh/MocA family oxidoreductase -
LQ213_RS03200 (AI2699V1_0623) 669878..670099 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LQ213_RS03205 (AI2699V1_0624) 670096..670470 + 375 WP_016808034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LQ213_RS03210 (AI2699V1_0625) 670450..670953 - 504 WP_004105953.1 M48 family metallopeptidase -
LQ213_RS03215 (AI2699V1_0626) 671032..672675 - 1644 WP_064373438.1 glycoside hydrolase family 43 protein -
LQ213_RS03220 (AI2699V1_0627) 672804..673670 - 867 WP_004105950.1 AraC family transcriptional regulator -
LQ213_RS03225 (AI2699V1_0628) 673778..675121 + 1344 WP_016808032.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13835.89 Da        Isoelectric Point: 6.0752

>T295703 WP_016808034.1 NZ_OW849470:670096-670470 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHCEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT295703 WP_004105957.1 NZ_OW849470:669878-670099 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References