Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 83415..84445 | Replicon | chromosome |
| Accession | NZ_OW849470 | ||
| Organism | Klebsiella oxytoca isolate 325 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | LQ213_RS00410 | Protein ID | WP_230185787.1 |
| Coordinates | 83870..84445 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | LQ213_RS00405 | Protein ID | WP_004106993.1 |
| Coordinates | 83415..83870 (+) | Length | 152 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ213_RS00380 (AI2699V1_0077) | 79156..80109 | + | 954 | WP_200784413.1 | helix-turn-helix domain-containing protein | - |
| LQ213_RS00385 (AI2699V1_0078) | 80106..81155 | - | 1050 | WP_004107002.1 | NAD(P)-dependent alcohol dehydrogenase | - |
| LQ213_RS00390 (AI2699V1_0079) | 81314..81616 | - | 303 | WP_029779396.1 | putative quinol monooxygenase | - |
| LQ213_RS00395 (AI2699V1_0080) | 81618..82625 | - | 1008 | WP_200784410.1 | zinc-binding alcohol dehydrogenase family protein | - |
| LQ213_RS00400 (AI2699V1_0081) | 82738..83205 | - | 468 | WP_004106996.1 | DUF3237 domain-containing protein | - |
| LQ213_RS00405 (AI2699V1_0082) | 83415..83870 | + | 456 | WP_004106993.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LQ213_RS00410 (AI2699V1_0083) | 83870..84445 | + | 576 | WP_230185787.1 | PIN domain-containing protein | Toxin |
| LQ213_RS00415 | 84724..84846 | + | 123 | WP_094298907.1 | hypothetical protein | - |
| LQ213_RS00425 (AI2699V1_0084) | 85270..86664 | + | 1395 | WP_004106990.1 | glycoside-pentoside-hexuronide family transporter | - |
| LQ213_RS00430 (AI2699V1_0085) | 86678..88996 | + | 2319 | WP_064372363.1 | alpha-xylosidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21805.48 Da Isoelectric Point: 7.2060
>T295702 WP_230185787.1 NZ_OW849470:83870-84445 [Klebsiella oxytoca]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRCIQDEWCRNLIANRPDILPETLQRTVKMMNSALPDANVTGY
KGLISNLHLPDPNDRHVLAAAIRAKAEIIVTLNHKNFPPELLGPYEIETLHPDAFISDLFDLNHALTLEAVRRQRLSLKH
PSMAVDEFLEMLLKQGLPMTVKELAHYQYAI
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRCIQDEWCRNLIANRPDILPETLQRTVKMMNSALPDANVTGY
KGLISNLHLPDPNDRHVLAAAIRAKAEIIVTLNHKNFPPELLGPYEIETLHPDAFISDLFDLNHALTLEAVRRQRLSLKH
PSMAVDEFLEMLLKQGLPMTVKELAHYQYAI
Download Length: 576 bp
Antitoxin
Download Length: 152 a.a. Molecular weight: 17068.56 Da Isoelectric Point: 6.4953
>AT295702 WP_004106993.1 NZ_OW849470:83415-83870 [Klebsiella oxytoca]
MTTLTHLNLPDRQESELAQRGQRELAAYLSTRLETQRIAIVGEDDKAHTIELPTSALTLLMEILGELASGNAVQIVPVHA
ELTTQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQSLADQAQDLGMY
MTTLTHLNLPDRQESELAQRGQRELAAYLSTRLETQRIAIVGEDDKAHTIELPTSALTLLMEILGELASGNAVQIVPVHA
ELTTQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQSLADQAQDLGMY
Download Length: 456 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|