Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 88830..89455 Replicon plasmid P1
Accession NZ_OW849378
Organism Escherichia coli isolate 162

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ158_RS23610 Protein ID WP_000911313.1
Coordinates 89057..89455 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag LQ158_RS23605 Protein ID WP_000450520.1
Coordinates 88830..89057 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ158_RS23605 (88830) 88830..89057 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
LQ158_RS23610 (89057) 89057..89455 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ158_RS23615 (89464) 89464..91617 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
LQ158_RS23620 (91870) 91870..92601 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
LQ158_RS23625 (92633) 92633..93130 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / sul3 / ant(3'')-Ia / dfrA1 / tet(A) / sitABCD iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA 1..145050 145050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T295698 WP_000911313.1 NZ_OW849378:89057-89455 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT295698 WP_000450520.1 NZ_OW849378:88830-89057 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References