Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4288745..4289242 Replicon chromosome
Accession NZ_OW849377
Organism Escherichia coli isolate 162

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ158_RS20625 Protein ID WP_001173343.1
Coordinates 4288745..4288918 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag LQ158_RS20630 Protein ID WP_000398619.1
Coordinates 4288946..4289242 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ158_RS20615 (4285415) 4285415..4286872 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
LQ158_RS20620 (4287109) 4287109..4288626 + 1518 WP_001295074.1 lysine--tRNA ligase -
LQ158_RS20625 (4288745) 4288745..4288918 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ158_RS20630 (4288946) 4288946..4289242 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ158_RS20635 (4289469) 4289469..4289741 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ158_RS20640 (4289753) 4289753..4289983 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
LQ158_RS20645 (4290164) 4290164..4291795 + 1632 WP_001216486.1 sensor histidine kinase -
LQ158_RS20650 (4291792) 4291792..4292511 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295692 WP_001173343.1 NZ_OW849377:c4288918-4288745 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT295692 WP_000398619.1 NZ_OW849377:c4289242-4288946 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References