Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4190952..4191547 Replicon chromosome
Accession NZ_OW849377
Organism Escherichia coli isolate 162

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LQ158_RS20120 Protein ID WP_000239579.1
Coordinates 4190952..4191302 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag LQ158_RS20125 Protein ID WP_001223207.1
Coordinates 4191296..4191547 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ158_RS20100 (4186228) 4186228..4187250 - 1023 WP_001296689.1 ABC transporter permease -
LQ158_RS20105 (4187264) 4187264..4188766 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
LQ158_RS20110 (4189076) 4189076..4190032 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ158_RS20115 (4190342) 4190342..4190872 + 531 WP_000055072.1 inorganic diphosphatase -
LQ158_RS20120 (4190952) 4190952..4191302 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LQ158_RS20125 (4191296) 4191296..4191547 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ158_RS20130 (4191760) 4191760..4192101 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ158_RS20135 (4192104) 4192104..4195883 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T295691 WP_000239579.1 NZ_OW849377:c4191302-4190952 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT295691 WP_001223207.1 NZ_OW849377:c4191547-4191296 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References