295688

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3550539..3551376 Replicon chromosome
Accession NZ_OW849377
Organism Escherichia coli isolate 162

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag LQ158_RS17185 Protein ID WP_000227784.1
Coordinates 3550834..3551376 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag LQ158_RS17180 Protein ID WP_001297137.1
Coordinates 3550539..3550850 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ158_RS17155 (3545559) 3545559..3546506 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
LQ158_RS17160 (3546528) 3546528..3548519 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
LQ158_RS17165 (3548509) 3548509..3549123 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
LQ158_RS17170 (3549123) 3549123..3549452 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
LQ158_RS17175 (3549464) 3549464..3550354 + 891 WP_000971336.1 heme o synthase -
LQ158_RS17180 (3550539) 3550539..3550850 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
LQ158_RS17185 (3550834) 3550834..3551376 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
LQ158_RS17190 (3551432) 3551432..3552367 - 936 WP_001297127.1 tetratricopeptide repeat protein -
LQ158_RS17195 (3552775) 3552775..3554139 + 1365 WP_023143167.1 MFS transporter -
LQ158_RS17200 (3554267) 3554267..3554758 - 492 WP_001138904.1 nucleotide binding protein YajQ -
LQ158_RS17205 (3554926) 3554926..3555837 + 912 WP_000705877.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T295688 WP_000227784.1 NZ_OW849377:3550834-3551376 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT295688 WP_001297137.1 NZ_OW849377:3550539-3550850 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References