Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3516450..3517068 Replicon chromosome
Accession NZ_OW849377
Organism Escherichia coli isolate 162

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ158_RS17015 Protein ID WP_001291435.1
Coordinates 3516850..3517068 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ158_RS17010 Protein ID WP_000344800.1
Coordinates 3516450..3516824 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ158_RS17000 (3511539) 3511539..3512732 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ158_RS17005 (3512755) 3512755..3515904 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ158_RS17010 (3516450) 3516450..3516824 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ158_RS17015 (3516850) 3516850..3517068 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ158_RS17020 (3517239) 3517239..3517790 + 552 WP_000102578.1 maltose O-acetyltransferase -
LQ158_RS17025 (3517906) 3517906..3518376 + 471 WP_000136192.1 YlaC family protein -
LQ158_RS17030 (3518540) 3518540..3520090 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ158_RS17035 (3520132) 3520132..3520485 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LQ158_RS17045 (3520864) 3520864..3521175 + 312 WP_000409911.1 MGMT family protein -
LQ158_RS17050 (3521206) 3521206..3521778 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295687 WP_001291435.1 NZ_OW849377:3516850-3517068 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295687 WP_000344800.1 NZ_OW849377:3516450-3516824 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References