Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4153757..4154436 Replicon chromosome
Accession NZ_OW849195
Organism Enterobacter cloacae isolate 125

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LQ145_RS20115 Protein ID WP_014641112.1
Coordinates 4153757..4154098 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LQ145_RS20120 Protein ID WP_001004647.1
Coordinates 4154119..4154436 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ145_RS20095 (AI2762V1_3920) 4149031..4150776 + 1746 WP_014885284.1 DNA primase -
LQ145_RS20100 (AI2762V1_3921) 4150942..4152786 + 1845 WP_014885285.1 RNA polymerase sigma factor RpoD -
LQ145_RS20105 (AI2762V1_3922) 4152888..4153394 - 507 WP_014885286.1 G/U mismatch-specific DNA glycosylase -
LQ145_RS20115 (AI2762V1_3923) 4153757..4154098 - 342 WP_014641112.1 TA system toxin CbtA family protein Toxin
LQ145_RS20120 (AI2762V1_3924) 4154119..4154436 - 318 WP_001004647.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LQ145_RS20125 (AI2762V1_3925) 4154465..4154947 - 483 WP_180837426.1 DNA repair protein RadC -
LQ145_RS20130 (AI2762V1_3926) 4154956..4155414 - 459 WP_000211839.1 antirestriction protein -
LQ145_RS20135 (AI2762V1_3927) 4155516..4155755 - 240 WP_001115184.1 DUF905 domain-containing protein -
LQ145_RS20140 (AI2762V1_3928) 4155846..4159313 - 3468 WP_283942670.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13031.28 Da        Isoelectric Point: 10.5786

>T295673 WP_014641112.1 NZ_OW849195:c4154098-4153757 [Enterobacter cloacae]
MKTLPATTLRVVKPCLSPVAVWKMLLTRLLEQHYGLTLNDTPFSKERVIQEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRKNLVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12111.73 Da        Isoelectric Point: 6.6252

>AT295673 WP_001004647.1 NZ_OW849195:c4154436-4154119 [Enterobacter cloacae]
VNEMTWGLQRDVTPRFGVRLVQESNRLHYLSDRASITGKFSDVECLRLDEAFPHFVRQMELMLTTGDLNPRHTHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References