Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3942295..3942952 Replicon chromosome
Accession NZ_OW849195
Organism Enterobacter cloacae isolate 125

Toxin (Protein)


Gene name cptA Uniprot ID A0A2W0G6Z0
Locus tag LQ145_RS19120 Protein ID WP_014885136.1
Coordinates 3942295..3942705 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LQ145_RS19125 Protein ID WP_010435322.1
Coordinates 3942686..3942952 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ145_RS19100 (AI2762V1_3727) 3938289..3940022 - 1734 WP_023331239.1 single-stranded-DNA-specific exonuclease RecJ -
LQ145_RS19105 (AI2762V1_3728) 3940028..3940741 - 714 WP_014885133.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ145_RS19110 (AI2762V1_3729) 3940770..3941666 - 897 WP_014885134.1 site-specific tyrosine recombinase XerD -
LQ145_RS19115 (AI2762V1_3730) 3941768..3942289 + 522 WP_014885135.1 flavodoxin FldB -
LQ145_RS19120 (AI2762V1_3731) 3942295..3942705 - 411 WP_014885136.1 protein YgfX Toxin
LQ145_RS19125 (AI2762V1_3732) 3942686..3942952 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LQ145_RS19130 (AI2762V1_3733) 3943247..3944227 + 981 WP_023331241.1 tRNA-modifying protein YgfZ -
LQ145_RS19135 (AI2762V1_3734) 3944312..3944971 - 660 WP_023331242.1 hemolysin III family protein -
LQ145_RS19140 (AI2762V1_3735) 3945237..3945968 + 732 WP_014885139.1 MurR/RpiR family transcriptional regulator -
LQ145_RS19145 (AI2762V1_3736) 3946085..3947518 + 1434 WP_023331244.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.04 Da        Isoelectric Point: 10.7510

>T295672 WP_014885136.1 NZ_OW849195:c3942705-3942295 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLMLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNSGMMLRLRNVDGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT295672 WP_010435322.1 NZ_OW849195:c3942952-3942686 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G6Z0

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References