29567

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 870420..870897 Replicon chromosome
Accession NC_021554
Organism Staphylococcus aureus CA-347

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CA347_RS04165 Protein ID WP_000052076.1
Coordinates 870420..870608 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CA347_RS04170 Protein ID WP_001059690.1
Coordinates 870637..870897 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA347_RS04135 866410..866931 + 522 WP_000824479.1 hypothetical protein -
CA347_RS04140 867272..867958 + 687 WP_001622483.1 thermonuclease family protein -
CA347_RS04145 868315..868515 + 201 WP_001059082.1 cold-shock protein -
CA347_RS04150 869012..869230 - 219 WP_000005875.1 hypothetical protein -
CA347_RS04155 869303..869575 - 273 WP_001004400.1 hypothetical protein -
CA347_RS04160 869663..870232 - 570 WP_001106662.1 hypothetical protein -
CA347_RS04165 870420..870608 - 189 WP_000052076.1 hypothetical protein Toxin
CA347_RS04170 870637..870897 - 261 WP_001059690.1 hypothetical protein Antitoxin
CA347_RS04175 871238..871441 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
CA347_RS04180 871438..871674 - 237 WP_000368687.1 hypothetical protein -
CA347_RS04185 871898..872479 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CA347_RS04190 872552..873169 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
CA347_RS04195 873325..873819 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CA347_RS04200 874218..874640 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
CA347_RS04205 874788..875504 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T29567 WP_000052076.1 NC_021554:c870608-870420 [Staphylococcus aureus CA-347]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T29567 NC_021554:c870608-870420 [Staphylococcus aureus CA-347]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT29567 WP_001059690.1 NC_021554:c870897-870637 [Staphylococcus aureus CA-347]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT29567 NC_021554:c870897-870637 [Staphylococcus aureus CA-347]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References