Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1843745..1844542 Replicon chromosome
Accession NZ_OW849195
Organism Enterobacter cloacae isolate 125

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag LQ145_RS09045 Protein ID WP_176450254.1
Coordinates 1844018..1844542 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID A0A2W0G3H3
Locus tag LQ145_RS09040 Protein ID WP_014883303.1
Coordinates 1843745..1844014 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ145_RS09010 (AI2762V1_1755) 1839366..1839866 + 501 WP_014883299.1 DedA family protein -
LQ145_RS09015 (AI2762V1_1756) 1839970..1841211 + 1242 WP_023332655.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
LQ145_RS09020 (AI2762V1_1757) 1841245..1841472 - 228 WP_014883300.1 YccJ family protein -
LQ145_RS09025 (AI2762V1_1758) 1841491..1842087 - 597 WP_014883301.1 NAD(P)H:quinone oxidoreductase -
LQ145_RS09030 (AI2762V1_1759) 1842479..1842649 + 171 WP_023332656.1 general stress protein -
LQ145_RS09035 (AI2762V1_1760) 1842766..1843683 + 918 WP_023332657.1 DMT family transporter -
LQ145_RS09040 (AI2762V1_1761) 1843745..1844014 + 270 WP_014883303.1 DUF1778 domain-containing protein Antitoxin
LQ145_RS09045 (AI2762V1_1762) 1844018..1844542 + 525 WP_176450254.1 GNAT family N-acetyltransferase Toxin
LQ145_RS09050 (AI2762V1_1763) 1844616..1845938 - 1323 WP_014883305.1 pyrimidine utilization transport protein G -
LQ145_RS09055 (AI2762V1_1764) 1845960..1846454 - 495 WP_023332659.1 pyrimidine utilization flavin reductase protein F -
LQ145_RS09060 (AI2762V1_1765) 1846464..1847054 - 591 WP_014883307.1 malonic semialdehyde reductase -
LQ145_RS09065 (AI2762V1_1766) 1847064..1847864 - 801 WP_023332660.1 pyrimidine utilization protein D -
LQ145_RS09070 (AI2762V1_1767) 1847872..1848258 - 387 WP_023332661.1 pyrimidine utilization protein C -
LQ145_RS09075 (AI2762V1_1768) 1848270..1848959 - 690 WP_014883310.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19689.59 Da        Isoelectric Point: 8.9464

>T295667 WP_176450254.1 NZ_OW849195:1844018-1844542 [Enterobacter cloacae]
IVANLTIEMFSEGSDYDFRGFDCGEPSLNAFLTEHLVRQHKGRILRGYLLKDRDHPRVLGYYTLSGSCFEKAMLPSKTQQ
RRIPYVNVPSVTLGRLAVHKDLQGKEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNEQAKRFYLKQGFIPLTGENSHSL
FFPTKSIEQLFEQA

Download         Length: 525 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10278.72 Da        Isoelectric Point: 5.8836

>AT295667 WP_014883303.1 NZ_OW849195:1843745-1844014 [Enterobacter cloacae]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNESSWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0G3H3

References