Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1110936..1111556 Replicon chromosome
Accession NZ_OW849195
Organism Enterobacter cloacae isolate 125

Toxin (Protein)


Gene name Hha Uniprot ID A0A2W0G488
Locus tag LQ145_RS05330 Protein ID WP_014882802.1
Coordinates 1110936..1111154 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LQ145_RS05335 Protein ID WP_008499288.1
Coordinates 1111182..1111556 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ145_RS05300 (AI2762V1_1030) 1106945..1107205 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
LQ145_RS05305 (AI2762V1_1031) 1107208..1107348 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LQ145_RS05310 (AI2762V1_1032) 1107345..1108055 - 711 WP_014882798.1 GNAT family protein -
LQ145_RS05315 (AI2762V1_1033) 1108157..1109617 + 1461 Protein_1032 PLP-dependent aminotransferase family protein -
LQ145_RS05320 (AI2762V1_1034) 1109589..1110056 - 468 WP_014882800.1 YlaC family protein -
LQ145_RS05325 (AI2762V1_1035) 1110175..1110726 - 552 WP_014882801.1 maltose O-acetyltransferase -
LQ145_RS05330 (AI2762V1_1036) 1110936..1111154 - 219 WP_014882802.1 HHA domain-containing protein Toxin
LQ145_RS05335 (AI2762V1_1037) 1111182..1111556 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LQ145_RS05340 (AI2762V1_1038) 1112068..1115214 - 3147 WP_014882803.1 multidrug efflux RND transporter permease subunit AcrB -
LQ145_RS05345 (AI2762V1_1039) 1115237..1116430 - 1194 WP_014882804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T295665 WP_014882802.1 NZ_OW849195:c1111154-1110936 [Enterobacter cloacae]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT295665 WP_008499288.1 NZ_OW849195:c1111556-1111182 [Enterobacter cloacae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G488

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References