Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4684415..4685031 Replicon chromosome
Accession NZ_OW849099
Organism Citrobacter freundii isolate 402

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag LQ100_RS22365 Protein ID WP_003028682.1
Coordinates 4684415..4684789 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQ100_RS22370 Protein ID WP_161958353.1
Coordinates 4684789..4685031 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ100_RS22350 (4681918) 4681918..4682820 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
LQ100_RS22355 (4682817) 4682817..4683452 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LQ100_RS22360 (4683449) 4683449..4684378 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
LQ100_RS22365 (4684415) 4684415..4684789 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ100_RS22370 (4684789) 4684789..4685031 - 243 WP_161958353.1 CopG family transcriptional regulator Antitoxin
LQ100_RS22375 (4685238) 4685238..4686146 + 909 WP_060854620.1 alpha/beta hydrolase -
LQ100_RS22380 (4686297) 4686297..4687238 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LQ100_RS22385 (4687283) 4687283..4687720 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
LQ100_RS22390 (4687717) 4687717..4688589 - 873 WP_060854619.1 virulence factor BrkB family protein -
LQ100_RS22395 (4688583) 4688583..4689182 - 600 WP_016151258.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T295662 WP_003028682.1 NZ_OW849099:c4684789-4684415 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9481.78 Da        Isoelectric Point: 4.3437

>AT295662 WP_161958353.1 NZ_OW849099:c4685031-4684789 [Citrobacter freundii]
MMTGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure

References