Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4278895..4279411 Replicon chromosome
Accession NZ_OW849099
Organism Citrobacter freundii isolate 402

Toxin (Protein)


Gene name relE Uniprot ID A0A133L8K5
Locus tag LQ100_RS20465 Protein ID WP_003844927.1
Coordinates 4278895..4279179 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag LQ100_RS20470 Protein ID WP_003839576.1
Coordinates 4279169..4279411 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ100_RS20450 (4274121) 4274121..4275773 + 1653 WP_230142563.1 alpha,alpha-phosphotrehalase -
LQ100_RS20455 (4276182) 4276182..4278320 + 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
LQ100_RS20460 (4278427) 4278427..4278891 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ100_RS20465 (4278895) 4278895..4279179 - 285 WP_003844927.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ100_RS20470 (4279169) 4279169..4279411 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ100_RS20475 (4279489) 4279489..4281402 - 1914 WP_003844930.1 BglG family transcription antiterminator -
LQ100_RS20480 (4281424) 4281424..4282164 - 741 WP_048216922.1 KDGP aldolase family protein -
LQ100_RS20485 (4282161) 4282161..4283279 - 1119 WP_048216923.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LQ100_RS20490 (4283263) 4283263..4284396 - 1134 WP_060855415.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10892.76 Da        Isoelectric Point: 10.0482

>T295661 WP_003844927.1 NZ_OW849099:c4279179-4278895 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLLYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT295661 WP_003839576.1 NZ_OW849099:c4279411-4279169 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133L8K5

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References