Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3578089..3578709 Replicon chromosome
Accession NZ_OW849099
Organism Citrobacter freundii isolate 402

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQ100_RS17230 Protein ID WP_002892050.1
Coordinates 3578491..3578709 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag LQ100_RS17225 Protein ID WP_003021733.1
Coordinates 3578089..3578463 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ100_RS17215 (3573236) 3573236..3574429 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ100_RS17220 (3574452) 3574452..3577601 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
LQ100_RS17225 (3578089) 3578089..3578463 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
LQ100_RS17230 (3578491) 3578491..3578709 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQ100_RS17235 (3579016) 3579016..3579567 + 552 WP_032936967.1 maltose O-acetyltransferase -
LQ100_RS17240 (3579684) 3579684..3580154 + 471 WP_003021724.1 YlaC family protein -
LQ100_RS17245 (3580233) 3580233..3580373 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LQ100_RS17250 (3580375) 3580375..3580635 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
LQ100_RS17255 (3580824) 3580824..3582377 + 1554 WP_003835927.1 EAL domain-containing protein -
LQ100_RS17260 (3582429) 3582429..3582782 - 354 WP_003831033.1 DUF1428 family protein -
LQ100_RS17265 (3582847) 3582847..3583476 - 630 WP_003021707.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295660 WP_002892050.1 NZ_OW849099:3578491-3578709 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT295660 WP_003021733.1 NZ_OW849099:3578089-3578463 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References