Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2890536..2891126 Replicon chromosome
Accession NZ_OW849099
Organism Citrobacter freundii isolate 402

Toxin (Protein)


Gene name pemK Uniprot ID A0A0J1NBD3
Locus tag LQ100_RS13965 Protein ID WP_003836692.1
Coordinates 2890536..2890868 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0J1NBD4
Locus tag LQ100_RS13970 Protein ID WP_003836694.1
Coordinates 2890869..2891126 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ100_RS13940 (2886289) 2886289..2887776 + 1488 WP_003846749.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
LQ100_RS13950 (2888092) 2888092..2889042 - 951 WP_016149950.1 HTH-type transcriptional regulator Cbl -
LQ100_RS13955 (2889144) 2889144..2890061 - 918 WP_054528287.1 nitrogen assimilation transcriptional regulator NAC -
LQ100_RS13965 (2890536) 2890536..2890868 - 333 WP_003836692.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LQ100_RS13970 (2890869) 2890869..2891126 - 258 WP_003836694.1 hypothetical protein Antitoxin
LQ100_RS13975 (2891740) 2891740..2895639 + 3900 WP_060855256.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2880139..2901508 21369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11703.48 Da        Isoelectric Point: 8.5572

>T295659 WP_003836692.1 NZ_OW849099:c2890868-2890536 [Citrobacter freundii]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9428.89 Da        Isoelectric Point: 4.3440

>AT295659 WP_003836694.1 NZ_OW849099:c2891126-2890869 [Citrobacter freundii]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NBD3

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1NBD4

References