Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 809225..809879 Replicon chromosome
Accession NZ_OW849099
Organism Citrobacter freundii isolate 402

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag LQ100_RS03960 Protein ID WP_003026936.1
Coordinates 809472..809879 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag LQ100_RS03955 Protein ID WP_003026938.1
Coordinates 809225..809491 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ100_RS03930 (804426) 804426..805859 - 1434 WP_048218552.1 6-phospho-beta-glucosidase BglA -
LQ100_RS03935 (805980) 805980..806708 - 729 WP_230142729.1 MurR/RpiR family transcriptional regulator -
LQ100_RS03940 (806761) 806761..807072 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
LQ100_RS03945 (807235) 807235..807894 + 660 WP_003838267.1 hemolysin III family protein -
LQ100_RS03950 (807988) 807988..808968 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
LQ100_RS03955 (809225) 809225..809491 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
LQ100_RS03960 (809472) 809472..809879 + 408 WP_003026936.1 protein YgfX Toxin
LQ100_RS03965 (809924) 809924..810445 - 522 WP_003026933.1 flavodoxin FldB -
LQ100_RS03970 (810559) 810559..811455 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
LQ100_RS03975 (811479) 811479..812192 + 714 WP_003026923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ100_RS03980 (812198) 812198..813931 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T295653 WP_003026936.1 NZ_OW849099:809472-809879 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT295653 WP_003026938.1 NZ_OW849099:809225-809491 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References