Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 235848..236479 Replicon chromosome
Accession NZ_OW849099
Organism Citrobacter freundii isolate 402

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag LQ100_RS01110 Protein ID WP_003837806.1
Coordinates 235848..236123 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag LQ100_RS01115 Protein ID WP_003837808.1
Coordinates 236120..236479 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ100_RS01100 (231899) 231899..234646 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
LQ100_RS01105 (234646) 234646..235770 + 1125 WP_032950438.1 ABC transporter permease -
LQ100_RS01110 (235848) 235848..236123 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ100_RS01115 (236120) 236120..236479 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ100_RS01120 (236592) 236592..236993 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
LQ100_RS01125 (237043) 237043..237621 - 579 WP_003023390.1 4'-phosphopantetheinyl transferase AcpT -
LQ100_RS01130 (237684) 237684..238733 - 1050 WP_003023393.1 AI-2E family transporter -
LQ100_RS01135 (238867) 238867..240084 + 1218 WP_003846164.1 MFS transporter -
LQ100_RS01140 (240088) 240088..240645 - 558 WP_003837816.1 DcrB family lipoprotein -
LQ100_RS01145 (240718) 240718..241383 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T295651 WP_003837806.1 NZ_OW849099:235848-236123 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT295651 WP_003837808.1 NZ_OW849099:236120-236479 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References