Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 43058..43605 Replicon plasmid pCAR1.3
Accession NC_021506
Organism Pseudomonas resinovorans NBRC 106553

Toxin (Protein)


Gene name relE Uniprot ID S6AKK9
Locus tag PCA10_RS28380 Protein ID WP_016502317.1
Coordinates 43058..43333 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S6AY38
Locus tag PCA10_RS28385 Protein ID WP_016502318.1
Coordinates 43333..43605 (-) Length 91 a.a.

Genomic Context

PCA10_RS29955PCA10_RS28370PCA10_RS28375PCA10_RS29960PCA10_RS28400PCA10_RS28405PCA10_RS29950PCA10_RS28360PCA10_RS28365PCA10_RS28380PCA10_RS28385PCA10_RS28390PCA10_RS28395PCA10_RS28410
Location: 39766..39972 (207 bp)
Type: Others
Protein ID: WP_016502316.1
Location: 40266..41246 (981 bp)
Type: Others
Protein ID: WP_011077862.1
Location: 41369..42394 (1026 bp)
Type: Others
Protein ID: WP_144277083.1
Location: 42645..42914 (270 bp)
Type: Others
Protein ID: WP_011077892.1
Location: 45011..45571 (561 bp)
Type: Others
Protein ID: WP_011077895.1
Location: 45575..46846 (1272 bp)
Type: Others
Protein ID: Protein_52
Location: 38064..38453 (390 bp)
Type: Others
Protein ID: WP_016502314.1
Location: 38434..39231 (798 bp)
Type: Others
Protein ID: WP_011077890.1
Location: 39240..39650 (411 bp)
Type: Others
Protein ID: WP_016502315.1
Location: 43058..43333 (276 bp)
Type: Toxin
Protein ID: WP_016502317.1
Location: 43333..43605 (273 bp)
Type: Antitoxin
Protein ID: WP_016502318.1
Location: 43619..44032 (414 bp)
Type: Others
Protein ID: WP_016502319.1
Location: 44039..44779 (741 bp)
Type: Others
Protein ID: WP_011077894.1
Location: 46933..47682 (750 bp)
Type: Others
Protein ID: WP_013100941.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PCA10_RS29950 (PCA10_p0410)38064..38453-390WP_016502314.1hypothetical protein-
PCA10_RS28360 (PCA10_p0420)38434..39231-798WP_011077890.1hypothetical protein-
PCA10_RS28365 (PCA10_p0430)39240..39650-411WP_016502315.1helix-turn-helix domain-containing protein-
PCA10_RS29955 (PCA10_p0440)39766..39972+207WP_016502316.1DNA-binding protein-
PCA10_RS28370 (PCA10_p0450)40266..41246+981WP_011077862.1IS5-like element ISPre1 family transposase-
PCA10_RS28375 (PCA10_p0460)41369..42394+1026WP_144277083.1bifunctional diguanylate cyclase/phosphodiesterase-
PCA10_RS29960 (PCA10_p0470)42645..42914+270WP_011077892.1hypothetical protein-
PCA10_RS28380 (PCA10_p0480)43058..43333-276WP_016502317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PCA10_RS28385 (PCA10_p0490)43333..43605-273WP_016502318.1ribbon-helix-helix domain-containing proteinAntitoxin
PCA10_RS28390 (PCA10_p0500)43619..44032-414WP_016502319.1hypothetical protein-
PCA10_RS28395 (PCA10_p0510)44039..44779-741WP_011077894.1DUF2807 domain-containing protein-
PCA10_RS28400 (PCA10_p0520)45011..45571+561WP_011077895.1recombinase family protein-
PCA10_RS28405 (PCA10_p0530)45575..46846+1272Protein_52DUF4158 domain-containing protein-
PCA10_RS28410 (PCA10_p0540)46933..47682-750WP_013100941.1IS21-like element helper ATPase IstB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..198965198965
-insideIScluster/Tn--40266..5643716171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10702.22 Da        Isoelectric Point: 7.2020

>T29565 WP_016502317.1 NC_021506:c43333-43058 [Pseudomonas resinovorans NBRC 106553]
MELKWTSKALSDIARLYEFLASVNQPAAARTVQQLTAAPSTLLANPRIGERLEEFDPRDVRRIQIGHYEMRYEIVDSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T29565 NC_021506:c43333-43058 [Pseudomonas resinovorans NBRC 106553]
ATGGAGTTGAAGTGGACAAGCAAGGCGCTTTCCGACATTGCCCGGTTGTATGAGTTTCTGGCGTCGGTGAATCAGCCTGC
CGCCGCACGAACAGTGCAGCAACTCACAGCCGCACCTTCCACGCTGCTGGCCAACCCGCGCATTGGCGAACGCCTGGAAG
AATTCGATCCACGGGATGTGCGCCGAATTCAGATCGGCCATTACGAGATGCGTTACGAGATAGTGGATTCCACTATCTAC
CTACTGCGCCTGTGGCACACCCGCGAAGACCGATAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10074.43 Da        Isoelectric Point: 5.7066

>AT29565 WP_016502318.1 NC_021506:c43605-43333 [Pseudomonas resinovorans NBRC 106553]
MATTAKTRSVTAHVPVQLAEKVDLMAERLERSKNWIVKQALAAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWAESL
STDTPLPVPR

Download         Length: 273 bp

>AT29565 NC_021506:c43605-43333 [Pseudomonas resinovorans NBRC 106553]
ATGGCAACCACCGCGAAAACCCGATCCGTCACGGCTCACGTCCCTGTGCAACTGGCCGAAAAGGTCGATTTGATGGCTGA
GCGCCTGGAACGCTCCAAGAACTGGATCGTCAAGCAGGCTCTGGCCGCCTGGATAGACCAGGAAGAAGAACGTAGTCGCC
TGACCCGTGAGGCATTGGCCGATGTGGATGCTGGTCGCGTGATCGATCATCAAGCTGTCCAGGCCTGGGCTGAAAGCCTC
AGCACTGACACTCCGTTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS6AKK9

Antitoxin

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Source
ID
Structure
AlphaFold DBS6AY38

References