Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4475788..4476304 Replicon chromosome
Accession NZ_OW849082
Organism Citrobacter freundii isolate 8

Toxin (Protein)


Gene name relE Uniprot ID A0A133L8K5
Locus tag LQ154_RS22215 Protein ID WP_003844927.1
Coordinates 4475788..4476072 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag LQ154_RS22220 Protein ID WP_003839576.1
Coordinates 4476062..4476304 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ154_RS22200 (4471014) 4471014..4472666 + 1653 WP_205461297.1 alpha,alpha-phosphotrehalase -
LQ154_RS22205 (4473075) 4473075..4475213 + 2139 WP_003844922.1 anaerobic ribonucleoside-triphosphate reductase -
LQ154_RS22210 (4475320) 4475320..4475784 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ154_RS22215 (4475788) 4475788..4476072 - 285 WP_003844927.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ154_RS22220 (4476062) 4476062..4476304 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ154_RS22225 (4476382) 4476382..4478295 - 1914 WP_003844930.1 BglG family transcription antiterminator -
LQ154_RS22230 (4478317) 4478317..4479057 - 741 WP_048216922.1 KDGP aldolase family protein -
LQ154_RS22235 (4479054) 4479054..4480172 - 1119 WP_054527995.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LQ154_RS22240 (4480156) 4480156..4481289 - 1134 WP_060855415.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10892.76 Da        Isoelectric Point: 10.0482

>T295644 WP_003844927.1 NZ_OW849082:c4476072-4475788 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLLYQVRDEVVIVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT295644 WP_003839576.1 NZ_OW849082:c4476304-4476062 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133L8K5

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References