Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3824335..3824955 Replicon chromosome
Accession NZ_OW849082
Organism Citrobacter freundii isolate 8

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQ154_RS19220 Protein ID WP_002892050.1
Coordinates 3824737..3824955 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag LQ154_RS19215 Protein ID WP_003021733.1
Coordinates 3824335..3824709 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ154_RS19205 (3819481) 3819481..3820674 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ154_RS19210 (3820697) 3820697..3823846 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
LQ154_RS19215 (3824335) 3824335..3824709 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
LQ154_RS19220 (3824737) 3824737..3824955 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQ154_RS19225 (3825262) 3825262..3825813 + 552 WP_003835924.1 maltose O-acetyltransferase -
LQ154_RS19230 (3825930) 3825930..3826400 + 471 WP_087879033.1 YlaC family protein -
LQ154_RS19235 (3826479) 3826479..3826619 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LQ154_RS19240 (3826621) 3826621..3826881 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
LQ154_RS19245 (3827070) 3827070..3828623 + 1554 WP_003835927.1 EAL domain-containing protein -
LQ154_RS19250 (3828675) 3828675..3829028 - 354 WP_003831033.1 DUF1428 family protein -
LQ154_RS19255 (3829093) 3829093..3829722 - 630 WP_003835929.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295643 WP_002892050.1 NZ_OW849082:3824737-3824955 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT295643 WP_003021733.1 NZ_OW849082:3824335-3824709 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References