Detailed information of TA system TA295642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 3055629..3056219
• Replicon: chromosome
• Accession: NZ_OW849082
• Organism: Citrobacter freundii isolate 8

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: A0A0J1NBD3
• Locus tag: LQ154_RS15235
• Protein ID: WP_003836692.1
• Coordinates: 3055629..3055961 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: A0A0J1NBD4
• Locus tag: LQ154_RS15240
• Protein ID: WP_003836694.1
• Coordinates: 3055962..3056219 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3054237..3075159	20922

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-109)

Antitoxin

• Antitoxin PemI-like (4-84)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11703.48 Da
• Isoelectric Point: 8.5572

>T295642 WP_003836692.1 NZ_OW849082:c3055961-3055629 [Citrobacter freundii]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKCLERIPEAVVNEVLARLEAILS

Nucleotide

• Length: 333 bp

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9428.89 Da
• Isoelectric Point: 4.3440

>AT295642 WP_003836694.1 NZ_OW849082:c3056219-3055962 [Citrobacter freundii]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWIDAPAV
GKEIL

Nucleotide

• Length: 258 bp

Structures

Toxin

• AlphaFold DB: A0A0J1NBD3

Antitoxin

• AlphaFold DB: A0A0J1NBD4