Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2515980..2516619 Replicon chromosome
Accession NZ_OW849082
Organism Citrobacter freundii isolate 8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LQ154_RS12490 Protein ID WP_071684398.1
Coordinates 2515980..2516156 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LQ154_RS12495 Protein ID WP_123924900.1
Coordinates 2516203..2516619 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ154_RS12470 (2512758) 2512758..2512988 - 231 WP_003020233.1 DUF2554 family protein -
LQ154_RS12475 (2513178) 2513178..2513303 - 126 WP_003020230.1 DUF2474 domain-containing protein -
LQ154_RS12480 (2513303) 2513303..2514313 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
LQ154_RS12485 (2514313) 2514313..2515716 - 1404 WP_003843730.1 cytochrome ubiquinol oxidase subunit I -
LQ154_RS12490 (2515980) 2515980..2516156 + 177 WP_071684398.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ154_RS12495 (2516203) 2516203..2516619 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ154_RS12500 (2516712) 2516712..2518121 + 1410 WP_003836140.1 PLP-dependent aminotransferase family protein -
LQ154_RS12505 (2518449) 2518449..2519594 + 1146 WP_003020212.1 ABC transporter substrate-binding protein -
LQ154_RS12510 (2519611) 2519611..2520627 + 1017 WP_119174242.1 ABC transporter ATP-binding protein -
LQ154_RS12515 (2520628) 2520628..2521572 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.86 Da        Isoelectric Point: 11.6208

>T295641 WP_071684398.1 NZ_OW849082:2515980-2516156 [Citrobacter freundii]
VKQSKFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT295641 WP_123924900.1 NZ_OW849082:2516203-2516619 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References