Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 906073..906727 Replicon chromosome
Accession NZ_OW849082
Organism Citrobacter freundii isolate 8

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag LQ154_RS04465 Protein ID WP_003026936.1
Coordinates 906320..906727 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag LQ154_RS04460 Protein ID WP_003026938.1
Coordinates 906073..906339 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ154_RS04435 (901273) 901273..902706 - 1434 WP_048218552.1 6-phospho-beta-glucosidase BglA -
LQ154_RS04440 (902828) 902828..903556 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
LQ154_RS04445 (903609) 903609..903920 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
LQ154_RS04450 (904083) 904083..904742 + 660 WP_003026947.1 hemolysin III family protein -
LQ154_RS04455 (904836) 904836..905816 - 981 WP_119174530.1 tRNA-modifying protein YgfZ -
LQ154_RS04460 (906073) 906073..906339 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
LQ154_RS04465 (906320) 906320..906727 + 408 WP_003026936.1 protein YgfX Toxin
LQ154_RS04470 (906772) 906772..907293 - 522 WP_003026933.1 flavodoxin FldB -
LQ154_RS04475 (907407) 907407..908303 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
LQ154_RS04480 (908327) 908327..909040 + 714 WP_230129561.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ154_RS04485 (909046) 909046..910779 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T295635 WP_003026936.1 NZ_OW849082:906320-906727 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT295635 WP_003026938.1 NZ_OW849082:906073-906339 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References