Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 265767..266398 Replicon chromosome
Accession NZ_OW849082
Organism Citrobacter freundii isolate 8

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag LQ154_RS01240 Protein ID WP_003837806.1
Coordinates 265767..266042 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag LQ154_RS01245 Protein ID WP_003837808.1
Coordinates 266039..266398 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ154_RS01230 (261818) 261818..264565 + 2748 WP_032937231.1 ribosome-associated ATPase/putative transporter RbbA -
LQ154_RS01235 (264565) 264565..265689 + 1125 WP_003837801.1 ABC transporter permease -
LQ154_RS01240 (265767) 265767..266042 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ154_RS01245 (266039) 266039..266398 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ154_RS01250 (266511) 266511..266912 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
LQ154_RS01255 (266962) 266962..267540 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
LQ154_RS01260 (267603) 267603..268652 - 1050 WP_003023393.1 AI-2E family transporter -
LQ154_RS01265 (268786) 268786..270003 + 1218 WP_016151126.1 MFS transporter -
LQ154_RS01270 (270007) 270007..270564 - 558 WP_003837816.1 DcrB family lipoprotein -
LQ154_RS01275 (270637) 270637..271302 - 666 WP_119174639.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T295632 WP_003837806.1 NZ_OW849082:265767-266042 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT295632 WP_003837808.1 NZ_OW849082:266039-266398 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References