295625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 59630..60189 Replicon plasmid P1
Accession NZ_OW849065
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name relE Uniprot ID V0SVC8
Locus tag LQ135_RS25930 Protein ID WP_000421272.1
Coordinates 59914..60189 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SRR3
Locus tag LQ135_RS25925 Protein ID WP_001387467.1
Coordinates 59630..59914 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS25900 (55093) 55093..55533 - 441 Protein_67 zinc-binding dehydrogenase -
LQ135_RS25905 (55934) 55934..56824 + 891 WP_001077068.1 dihydrodipicolinate synthase family protein -
LQ135_RS25910 (56849) 56849..57229 + 381 WP_000710783.1 Rid family detoxifying hydrolase -
LQ135_RS25915 (57262) 57262..58227 + 966 WP_001022265.1 2-keto-3-deoxygluconate transporter -
LQ135_RS25920 (58273) 58273..59025 - 753 WP_000562172.1 IclR family transcriptional regulator -
LQ135_RS25925 (59630) 59630..59914 + 285 WP_001387467.1 ribbon-helix-helix domain-containing protein Antitoxin
LQ135_RS25930 (59914) 59914..60189 + 276 WP_000421272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ135_RS25935 (60295) 60295..60498 + 204 Protein_74 hypothetical protein -
LQ135_RS25940 (60623) 60623..60751 - 129 Protein_75 IS481 family transposase -
LQ135_RS25945 (60784) 60784..61953 - 1170 WP_001072355.1 hypothetical protein -
LQ135_RS25950 (62485) 62485..62753 + 269 Protein_77 type II toxin-antitoxin system ParD family antitoxin -
LQ135_RS25955 (62740) 62740..63008 + 269 Protein_78 type II toxin-antitoxin system RelE/ParE family toxin -
LQ135_RS25960 (63042) 63042..63739 + 698 WP_095033700.1 IS1-like element IS1B family transposase -
LQ135_RS25965 (63993) 63993..65015 - 1023 WP_000361402.1 helicase UvrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / blaOXA-1 / aac(6')-Ib-cr / blaCTX-M-15 / aadA5 / qacE / sul1 - 1..146311 146311
- flank IS/Tn - - 63362..63739 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 10.0871

>T295625 WP_000421272.1 NZ_OW849065:59914-60189 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10460.87 Da        Isoelectric Point: 5.6558

>AT295625 WP_001387467.1 NZ_OW849065:59630-59914 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y880

References