Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4696380..4696998 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ135_RS23130 Protein ID WP_001291435.1
Coordinates 4696380..4696598 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ135_RS23135 Protein ID WP_000344800.1
Coordinates 4696624..4696998 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS23095 (4691667) 4691667..4692239 + 573 WP_000779831.1 YbaY family lipoprotein -
LQ135_RS23100 (4692270) 4692270..4692581 - 312 WP_000409908.1 MGMT family protein -
LQ135_RS23110 (4692960) 4692960..4693313 + 354 WP_000878135.1 DUF1428 family protein -
LQ135_RS23115 (4693355) 4693355..4694905 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ135_RS23120 (4695069) 4695069..4695539 - 471 WP_000136192.1 YlaC family protein -
LQ135_RS23125 (4695655) 4695655..4696206 - 552 WP_000102539.1 maltose O-acetyltransferase -
LQ135_RS23130 (4696380) 4696380..4696598 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ135_RS23135 (4696624) 4696624..4696998 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ135_RS23140 (4697544) 4697544..4700693 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
LQ135_RS23145 (4700716) 4700716..4701909 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295623 WP_001291435.1 NZ_OW849064:c4696598-4696380 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295623 WP_000344800.1 NZ_OW849064:c4696998-4696624 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References