295621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4245569..4246089 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag LQ135_RS20980 Protein ID WP_001160964.1
Coordinates 4245805..4246089 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag LQ135_RS20975 Protein ID WP_000125566.1
Coordinates 4245569..4245802 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS20950 (4240642) 4240642..4240929 + 288 WP_000203744.1 ferredoxin-like protein FixX -
LQ135_RS20955 (4240988) 4240988..4242319 + 1332 WP_001183209.1 MFS transporter -
LQ135_RS20960 (4242427) 4242427..4242957 + 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
LQ135_RS20965 (4242950) 4242950..4244812 + 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
LQ135_RS20970 (4245004) 4245004..4245483 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
LQ135_RS20975 (4245569) 4245569..4245802 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LQ135_RS20980 (4245805) 4245805..4246089 + 285 WP_001160964.1 CcdB family protein Toxin
LQ135_RS20985 (4246116) 4246116..4246964 - 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
LQ135_RS20990 (4246971) 4246971..4247348 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
LQ135_RS20995 (4247351) 4247351..4248172 - 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LQ135_RS21000 (4248169) 4248169..4249158 - 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
LQ135_RS21005 (4249158) 4249158..4250444 - 1287 WP_000800457.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T295621 WP_001160964.1 NZ_OW849064:4245805-4246089 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT295621 WP_000125566.1 NZ_OW849064:4245569-4245802 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References