295617

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3952531..3953126 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LQ135_RS19525 Protein ID WP_000239579.1
Coordinates 3952776..3953126 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LQ135_RS19520 Protein ID WP_001223208.1
Coordinates 3952531..3952782 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS19510 (3948196) 3948196..3951975 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
LQ135_RS19515 (3951978) 3951978..3952319 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ135_RS19520 (3952531) 3952531..3952782 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ135_RS19525 (3952776) 3952776..3953126 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LQ135_RS19530 (3953206) 3953206..3953736 - 531 WP_000055075.1 inorganic diphosphatase -
LQ135_RS19535 (3954046) 3954046..3955002 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ135_RS19540 (3955142) 3955142..3956644 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
LQ135_RS19545 (3956658) 3956658..3957680 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T295617 WP_000239579.1 NZ_OW849064:3952776-3953126 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT295617 WP_001223208.1 NZ_OW849064:3952531-3952782 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References