Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 3849528..3850025 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ135_RS18995 Protein ID WP_001173343.1
Coordinates 3849852..3850025 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID S1NQ59
Locus tag LQ135_RS18990 Protein ID WP_001312331.1
Coordinates 3849528..3849824 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS18980 (3844885) 3844885..3848814 + 3930 WP_001080129.1 autotransporter outer membrane beta-barrel domain-containing protein -
LQ135_RS18985 (3849028) 3849028..3849300 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ135_RS18990 (3849528) 3849528..3849824 + 297 WP_001312331.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ135_RS18995 (3849852) 3849852..3850025 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ135_RS19000 (3850144) 3850144..3851661 - 1518 WP_000003806.1 lysine--tRNA ligase -
LQ135_RS19005 (3851898) 3851898..3853355 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3833937..3858879 24942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295616 WP_001173343.1 NZ_OW849064:3849852-3850025 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11440.95 Da        Isoelectric Point: 4.1705

>AT295616 WP_001312331.1 NZ_OW849064:3849528-3849824 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLSIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB S1NQ59

References