Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2925652..2926452 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag LQ135_RS14635 Protein ID WP_000342452.1
Coordinates 2925652..2926179 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag LQ135_RS14640 Protein ID WP_001277107.1
Coordinates 2926186..2926452 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS14610 (2920728) 2920728..2921495 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LQ135_RS14615 (2921492) 2921492..2922769 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
LQ135_RS14620 (2922766) 2922766..2923692 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LQ135_RS14625 (2923740) 2923740..2924849 - 1110 WP_230181303.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LQ135_RS14630 (2925272) 2925272..2925655 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
LQ135_RS14635 (2925652) 2925652..2926179 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LQ135_RS14640 (2926186) 2926186..2926452 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LQ135_RS14645 (2926601) 2926601..2927704 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LQ135_RS14650 (2927975) 2927975..2928829 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LQ135_RS14655 (2929074) 2929074..2930132 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
LQ135_RS14660 (2930125) 2930125..2930793 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T295613 WP_000342452.1 NZ_OW849064:c2926179-2925652 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT295613 WP_001277107.1 NZ_OW849064:c2926452-2926186 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References