295610

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 2396973..2398254 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name sanaT Uniprot ID A0A1X3JHM4
Locus tag LQ135_RS12025 Protein ID WP_001114681.1
Coordinates 2397361..2398254 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID V0YCI1
Locus tag LQ135_RS12020 Protein ID WP_000208383.1
Coordinates 2396973..2397368 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS11975 (2392467) 2392467..2392952 + 486 WP_000849566.1 antirestriction protein -
LQ135_RS11980 (2392968) 2392968..2393444 + 477 WP_001186726.1 RadC family protein -
LQ135_RS11985 (2393507) 2393507..2393728 + 222 WP_000692329.1 DUF987 domain-containing protein -
LQ135_RS11990 (2393747) 2393747..2394391 + 645 WP_000094916.1 hypothetical protein -
LQ135_RS11995 (2394441) 2394441..2394821 + 381 WP_001285598.1 type IV toxin-antitoxin system YeeU family antitoxin -
LQ135_RS12000 (2394898) 2394898..2395275 + 378 WP_000854689.1 TA system toxin CbtA family protein -
LQ135_RS12005 (2395272) 2395272..2395760 + 489 WP_000761699.1 DUF5983 family protein -
LQ135_RS12010 (2395777) 2395777..2395974 + 198 WP_000839293.1 DUF957 domain-containing protein -
LQ135_RS12015 (2396059) 2396059..2396904 + 846 WP_023281696.1 DUF4942 domain-containing protein -
LQ135_RS12020 (2396973) 2396973..2397368 + 396 WP_000208383.1 DUF6088 family protein Antitoxin
LQ135_RS12025 (2397361) 2397361..2398254 + 894 WP_001114681.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LQ135_RS12030 (2398725) 2398725..2398895 + 171 Protein_2366 IS110 family transposase -
LQ135_RS12035 (2399244) 2399244..2400743 + 1500 WP_000174401.1 IS21-like element ISEc10 family transposase -
LQ135_RS12040 (2400740) 2400740..2401495 + 756 Protein_2368 IS21-like element ISEc10 family helper ATPase IstB -
LQ135_RS12045 (2402121) 2402121..2403104 + 984 WP_001296394.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(34-292)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 34298.40 Da        Isoelectric Point: 5.9850

>T295610 WP_001114681.1 NZ_OW849064:2397361-2398254 [Escherichia coli]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN

Download         Length: 894 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14608.03 Da        Isoelectric Point: 11.3150

>AT295610 WP_000208383.1 NZ_OW849064:2396973-2397368 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3JHM4

Antitoxin

Source ID Structure
AlphaFold DB V0YCI1

References