295608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2248105..2248759 Replicon chromosome
Accession NZ_OW849064
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag LQ135_RS11225 Protein ID WP_000244765.1
Coordinates 2248105..2248512 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag LQ135_RS11230 Protein ID WP_000354050.1
Coordinates 2248493..2248759 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ135_RS11205 (2244062) 2244062..2245795 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
LQ135_RS11210 (2245801) 2245801..2246511 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ135_RS11215 (2246536) 2246536..2247432 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LQ135_RS11220 (2247544) 2247544..2248065 + 522 WP_001055874.1 flavodoxin FldB -
LQ135_RS11225 (2248105) 2248105..2248512 - 408 WP_000244765.1 protein YgfX Toxin
LQ135_RS11230 (2248493) 2248493..2248759 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
LQ135_RS11235 (2249002) 2249002..2249982 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
LQ135_RS11240 (2250059) 2250059..2250718 - 660 WP_000250275.1 hemolysin III family protein -
LQ135_RS11245 (2250882) 2250882..2251193 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
LQ135_RS11250 (2251238) 2251238..2252671 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T295608 WP_000244765.1 NZ_OW849064:c2248512-2248105 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT295608 WP_000354050.1 NZ_OW849064:c2248759-2248493 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References