Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4478220..4479264 Replicon chromosome
Accession NZ_OW848980
Organism Escherichia coli isolate 23

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag LQ157_RS21940 Protein ID WP_000019186.1
Coordinates 4478220..4478768 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag LQ157_RS21945 Protein ID WP_000287252.1
Coordinates 4478791..4479264 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ157_RS21905 (4473432) 4473432..4473983 - 552 WP_000515860.1 protein YmfL -
LQ157_RS21910 (4474027) 4474027..4474227 - 201 WP_000649477.1 YdaS family helix-turn-helix protein -
LQ157_RS21915 (4474318) 4474318..4474992 + 675 WP_000859462.1 LexA family transcriptional repressor -
LQ157_RS21920 (4475659) 4475659..4476021 + 363 WP_000135682.1 protein YfdP -
LQ157_RS21925 (4476087) 4476087..4476911 + 825 WP_015364383.1 DUF2303 family protein -
LQ157_RS21930 (4477098) 4477098..4477880 + 783 WP_000610754.1 hypothetical protein -
LQ157_RS21935 (4477917) 4477917..4478186 + 270 WP_001093912.1 pyocin activator PrtN family protein -
LQ157_RS21940 (4478220) 4478220..4478768 - 549 WP_000019186.1 hypothetical protein Toxin
LQ157_RS21945 (4478791) 4478791..4479264 - 474 WP_000287252.1 DUF4065 domain-containing protein Antitoxin
LQ157_RS21950 (4479569) 4479569..4479673 - 105 Protein_4310 tRNA-dihydrouridine synthase -
LQ157_RS21955 (4480036) 4480036..4480776 - 741 WP_001324389.1 DUF2713 family protein -
LQ157_RS25450 (4480771) 4480771..4481052 - 282 Protein_4312 DUF2713 domain-containing protein -
LQ157_RS21960 (4481370) 4481370..4481885 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
LQ157_RS21965 (4481927) 4481927..4482136 - 210 WP_001030593.1 CsbD family protein -
LQ157_RS21970 (4482252) 4482252..4483577 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
LQ157_RS21975 (4483650) 4483650..4484258 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4456775..4484258 27483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T295582 WP_000019186.1 NZ_OW848980:c4478768-4478220 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT295582 WP_000287252.1 NZ_OW848980:c4479264-4478791 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References