Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4366300..4366797 Replicon chromosome
Accession NZ_OW848980
Organism Escherichia coli isolate 23

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag LQ157_RS21395 Protein ID WP_001173343.1
Coordinates 4366300..4366473 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID J7RC38
Locus tag LQ157_RS21400 Protein ID WP_001425728.1
Coordinates 4366501..4366797 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ157_RS21385 (4362970) 4362970..4364427 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
LQ157_RS21390 (4364664) 4364664..4366181 + 1518 WP_001295074.1 lysine--tRNA ligase -
LQ157_RS21395 (4366300) 4366300..4366473 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
LQ157_RS21400 (4366501) 4366501..4366797 - 297 WP_001425728.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
LQ157_RS21405 (4367024) 4367024..4367296 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
LQ157_RS21410 (4367308) 4367308..4367538 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
LQ157_RS21415 (4367719) 4367719..4369350 + 1632 WP_001216487.1 sensor histidine kinase -
LQ157_RS21420 (4369347) 4369347..4370066 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - sfaX / papF / papE / papK / papJ / papD / papC / papH / papB / papI 4305332..4366797 61465


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T295581 WP_001173343.1 NZ_OW848980:c4366473-4366300 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11466.99 Da        Isoelectric Point: 4.2544

>AT295581 WP_001425728.1 NZ_OW848980:c4366797-4366501 [Escherichia coli]
MEGKNKFNTYVVSFNYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB J7RC38

References