Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4354505..4355337 | Replicon | chromosome |
| Accession | NZ_OW848980 | ||
| Organism | Escherichia coli isolate 23 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2X9SFA4 |
| Locus tag | LQ157_RS21350 | Protein ID | WP_001094442.1 |
| Coordinates | 4354963..4355337 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2Y0FLC6 |
| Locus tag | LQ157_RS21345 | Protein ID | WP_021525985.1 |
| Coordinates | 4354505..4354873 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQ157_RS21310 (4350396) | 4350396..4351076 | + | 681 | WP_001282919.1 | WYL domain-containing protein | - |
| LQ157_RS21315 (4351224) | 4351224..4351901 | + | 678 | WP_001097305.1 | hypothetical protein | - |
| LQ157_RS21320 (4351907) | 4351907..4352140 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| LQ157_RS21325 (4352230) | 4352230..4353048 | + | 819 | WP_001175169.1 | DUF932 domain-containing protein | - |
| LQ157_RS21330 (4353140) | 4353140..4353625 | + | 486 | WP_000206658.1 | antirestriction protein | - |
| LQ157_RS21335 (4353641) | 4353641..4354117 | + | 477 | WP_001367707.1 | RadC family protein | - |
| LQ157_RS21340 (4354204) | 4354204..4354425 | + | 222 | WP_000691819.1 | DUF987 domain-containing protein | - |
| LQ157_RS21345 (4354505) | 4354505..4354873 | + | 369 | WP_021525985.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LQ157_RS21350 (4354963) | 4354963..4355337 | + | 375 | WP_001094442.1 | TA system toxin CbtA family protein | Toxin |
| LQ157_RS21355 (4355334) | 4355334..4355822 | + | 489 | WP_000777553.1 | DUF5983 family protein | - |
| LQ157_RS21360 (4355834) | 4355834..4356031 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| LQ157_RS21365 (4356128) | 4356128..4356697 | + | 570 | WP_001290249.1 | DUF4942 domain-containing protein | - |
| LQ157_RS21370 (4357446) | 4357446..4358984 | + | 1539 | WP_001187182.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | sfaX / papF / papE / papK / papJ / papD / papC / papH / papB / papI | 4305332..4366797 | 61465 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14072.01 Da Isoelectric Point: 7.8281
>T295580 WP_001094442.1 NZ_OW848980:4354963-4355337 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MNTLPDTHVREASHCQSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T295580 NZ_OW848980:4354963-4355337 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13690.48 Da Isoelectric Point: 6.4768
>AT295580 WP_021525985.1 NZ_OW848980:4354505-4354873 [Escherichia coli]
VSDTLPGTTHPDDNNDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDDNNDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT295580 NZ_OW848980:4354505-4354873 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCACCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGATAACAACGACCACCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2X9SFA4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2Y0FLC6 |