Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4208506..4209101 Replicon chromosome
Accession NZ_OW848980
Organism Escherichia coli isolate 23

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LQ157_RS20570 Protein ID WP_000239579.1
Coordinates 4208506..4208856 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LQ157_RS20575 Protein ID WP_001223208.1
Coordinates 4208850..4209101 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ157_RS20550 (4203782) 4203782..4204804 - 1023 WP_001339490.1 ABC transporter permease -
LQ157_RS20555 (4204818) 4204818..4206320 - 1503 WP_181204826.1 sugar ABC transporter ATP-binding protein -
LQ157_RS20560 (4206630) 4206630..4207586 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ157_RS20565 (4207896) 4207896..4208426 + 531 WP_000055072.1 inorganic diphosphatase -
LQ157_RS20570 (4208506) 4208506..4208856 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LQ157_RS20575 (4208850) 4208850..4209101 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ157_RS20580 (4209314) 4209314..4209655 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ157_RS20585 (4209658) 4209658..4213437 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T295579 WP_000239579.1 NZ_OW848980:c4208856-4208506 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT295579 WP_001223208.1 NZ_OW848980:c4209101-4208850 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References