Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3548993..3549611 Replicon chromosome
Accession NZ_OW848980
Organism Escherichia coli isolate 23

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ157_RS17415 Protein ID WP_001291435.1
Coordinates 3549393..3549611 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ157_RS17410 Protein ID WP_000344800.1
Coordinates 3548993..3549367 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ157_RS17400 (3544082) 3544082..3545275 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ157_RS17405 (3545298) 3545298..3548447 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LQ157_RS17410 (3548993) 3548993..3549367 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ157_RS17415 (3549393) 3549393..3549611 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ157_RS17420 (3549783) 3549783..3550334 + 552 WP_000102568.1 maltose O-acetyltransferase -
LQ157_RS17425 (3550450) 3550450..3550920 + 471 WP_000136192.1 YlaC family protein -
LQ157_RS17430 (3551084) 3551084..3552634 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ157_RS17435 (3552676) 3552676..3553029 - 354 Protein_3421 DUF1428 family protein -
LQ157_RS17445 (3553408) 3553408..3553719 + 312 WP_000409911.1 MGMT family protein -
LQ157_RS17450 (3553750) 3553750..3554322 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295578 WP_001291435.1 NZ_OW848980:3549393-3549611 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295578 WP_000344800.1 NZ_OW848980:3548993-3549367 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References