Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 276471..277057 Replicon chromosome
Accession NZ_OW848980
Organism Escherichia coli isolate 23

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag LQ157_RS01280 Protein ID WP_042014162.1
Coordinates 276471..276701 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag LQ157_RS01285 Protein ID WP_000593555.1
Coordinates 276698..277057 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ157_RS01270 (272508) 272508..275243 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
LQ157_RS01275 (275243) 275243..276367 + 1125 WP_001314210.1 ABC transporter permease -
LQ157_RS01280 (276471) 276471..276701 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
LQ157_RS01285 (276698) 276698..277057 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQ157_RS01290 (277177) 277177..277578 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
LQ157_RS01295 (277584) 277584..278390 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
LQ157_RS01300 (278387) 278387..279151 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
LQ157_RS01305 (279151) 279151..279984 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
LQ157_RS01310 (279981) 279981..280925 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T295563 WP_042014162.1 NZ_OW848980:276471-276701 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT295563 WP_000593555.1 NZ_OW848980:276698-277057 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References