Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4891143..4891759 Replicon chromosome
Accession NZ_OW848788
Organism Citrobacter freundii isolate 112

Toxin (Protein)


Gene name vapC Uniprot ID A0A0J1MQ96
Locus tag LQ087_RS23780 Protein ID WP_003028682.1
Coordinates 4891143..4891517 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6B5NTK4
Locus tag LQ087_RS23785 Protein ID WP_043018956.1
Coordinates 4891517..4891759 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ087_RS23765 (4888646) 4888646..4889548 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
LQ087_RS23770 (4889545) 4889545..4890180 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
LQ087_RS23775 (4890177) 4890177..4891106 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
LQ087_RS23780 (4891143) 4891143..4891517 - 375 WP_003028682.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ087_RS23785 (4891517) 4891517..4891759 - 243 WP_043018956.1 CopG family transcriptional regulator Antitoxin
LQ087_RS23790 (4891965) 4891965..4892873 + 909 WP_046671350.1 alpha/beta hydrolase -
LQ087_RS23795 (4893024) 4893024..4893965 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
LQ087_RS23800 (4894010) 4894010..4894447 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
LQ087_RS23805 (4894444) 4894444..4895316 - 873 WP_003028669.1 virulence factor BrkB family protein -
LQ087_RS23810 (4895310) 4895310..4895909 - 600 WP_046671351.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13674.89 Da        Isoelectric Point: 9.5622

>T295561 WP_003028682.1 NZ_OW848788:c4891517-4891143 [Citrobacter freundii]
MVKGSALFDTNILIDLFSGRNEAKLAIETWPPQNAISLITWMEVMVGAKKYHQEARTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTKDFAGLSGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9451.75 Da        Isoelectric Point: 4.3437

>AT295561 WP_043018956.1 NZ_OW848788:c4891759-4891517 [Citrobacter freundii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MQ96

Antitoxin

Source ID Structure
AlphaFold DB A0A6B5NTK4

References