Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4474406..4474922 Replicon chromosome
Accession NZ_OW848788
Organism Citrobacter freundii isolate 112

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LQ087_RS21825 Protein ID WP_044699148.1
Coordinates 4474406..4474690 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag LQ087_RS21830 Protein ID WP_003839576.1
Coordinates 4474680..4474922 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ087_RS21810 (4470731) 4470731..4471315 + 585 WP_003844920.1 fructose PTS transporter subunit IIA -
LQ087_RS21815 (4471693) 4471693..4473831 + 2139 WP_048234081.1 anaerobic ribonucleoside-triphosphate reductase -
LQ087_RS21820 (4473938) 4473938..4474402 + 465 WP_032937736.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LQ087_RS21825 (4474406) 4474406..4474690 - 285 WP_044699148.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LQ087_RS21830 (4474680) 4474680..4474922 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LQ087_RS21835 (4475000) 4475000..4476913 - 1914 WP_003839574.1 BglG family transcription antiterminator -
LQ087_RS21840 (4476935) 4476935..4477675 - 741 WP_003025772.1 KDGP aldolase family protein -
LQ087_RS21845 (4477672) 4477672..4478790 - 1119 WP_003025770.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LQ087_RS21850 (4478774) 4478774..4479907 - 1134 WP_016149471.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10865.69 Da        Isoelectric Point: 10.1988

>T295560 WP_044699148.1 NZ_OW848788:c4474690-4474406 [Citrobacter freundii]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
RQHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT295560 WP_003839576.1 NZ_OW848788:c4474922-4474680 [Citrobacter freundii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References