Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3757555..3758175 Replicon chromosome
Accession NZ_OW848788
Organism Citrobacter freundii isolate 112

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LQ087_RS18565 Protein ID WP_002892050.1
Coordinates 3757957..3758175 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag LQ087_RS18560 Protein ID WP_230122246.1
Coordinates 3757555..3757929 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ087_RS18550 (3752701) 3752701..3753894 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LQ087_RS18555 (3753917) 3753917..3757066 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
LQ087_RS18560 (3757555) 3757555..3757929 + 375 WP_230122246.1 Hha toxicity modulator TomB Antitoxin
LQ087_RS18565 (3757957) 3757957..3758175 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LQ087_RS18570 (3758482) 3758482..3759033 + 552 WP_003835924.1 maltose O-acetyltransferase -
LQ087_RS18575 (3759150) 3759150..3759620 + 471 WP_087879033.1 YlaC family protein -
LQ087_RS18580 (3759699) 3759699..3759839 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
LQ087_RS18585 (3759841) 3759841..3760101 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
LQ087_RS18590 (3760290) 3760290..3761843 + 1554 WP_003835927.1 EAL domain-containing protein -
LQ087_RS18595 (3761895) 3761895..3762248 - 354 WP_003831033.1 DUF1428 family protein -
LQ087_RS18600 (3762313) 3762313..3762942 - 630 WP_003835929.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295558 WP_002892050.1 NZ_OW848788:3757957-3758175 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT295558 WP_230122246.1 NZ_OW848788:3757555-3757929 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQINELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References