Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1105069..1105723 Replicon chromosome
Accession NZ_OW848788
Organism Citrobacter freundii isolate 112

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag LQ087_RS05410 Protein ID WP_003026936.1
Coordinates 1105069..1105476 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag LQ087_RS05415 Protein ID WP_003026938.1
Coordinates 1105457..1105723 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ087_RS05390 (1101017) 1101017..1102750 - 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -
LQ087_RS05395 (1102756) 1102756..1103469 - 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LQ087_RS05400 (1103493) 1103493..1104389 - 897 WP_230121762.1 site-specific tyrosine recombinase XerD -
LQ087_RS05405 (1104503) 1104503..1105024 + 522 WP_003026933.1 flavodoxin FldB -
LQ087_RS05410 (1105069) 1105069..1105476 - 408 WP_003026936.1 protein YgfX Toxin
LQ087_RS05415 (1105457) 1105457..1105723 - 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
LQ087_RS05420 (1105980) 1105980..1106960 + 981 WP_003838269.1 tRNA-modifying protein YgfZ -
LQ087_RS05425 (1107054) 1107054..1107713 - 660 WP_003838267.1 hemolysin III family protein -
LQ087_RS05430 (1107876) 1107876..1108187 - 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
LQ087_RS05435 (1108240) 1108240..1108968 + 729 WP_060855085.1 MurR/RpiR family transcriptional regulator -
LQ087_RS05440 (1109089) 1109089..1110522 + 1434 WP_230121763.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T295551 WP_003026936.1 NZ_OW848788:c1105476-1105069 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT295551 WP_003026938.1 NZ_OW848788:c1105723-1105457 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References