295535

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4085815..4086433 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LQ117_RS19660 Protein ID WP_001291435.1
Coordinates 4085815..4086033 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LQ117_RS19665 Protein ID WP_000344800.1
Coordinates 4086059..4086433 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS19625 (4081102) 4081102..4081674 + 573 WP_000779831.1 YbaY family lipoprotein -
LQ117_RS19630 (4081705) 4081705..4082016 - 312 WP_000409908.1 MGMT family protein -
LQ117_RS19640 (4082395) 4082395..4082748 + 354 WP_000878135.1 DUF1428 family protein -
LQ117_RS19645 (4082790) 4082790..4084340 - 1551 WP_001385227.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LQ117_RS19650 (4084504) 4084504..4084974 - 471 WP_000136192.1 YlaC family protein -
LQ117_RS19655 (4085090) 4085090..4085641 - 552 WP_000102539.1 maltose O-acetyltransferase -
LQ117_RS19660 (4085815) 4085815..4086033 - 219 WP_001291435.1 HHA domain-containing protein Toxin
LQ117_RS19665 (4086059) 4086059..4086433 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LQ117_RS19670 (4086979) 4086979..4090128 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
LQ117_RS19675 (4090151) 4090151..4091344 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T295535 WP_001291435.1 NZ_OW848785:c4086033-4085815 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT295535 WP_000344800.1 NZ_OW848785:c4086433-4086059 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References