Detailed information of TA system TA295534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3901438..3903127
• Replicon: chromosome
• Accession: NZ_OW848785
• Organism: Escherichia coli isolate 131

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: LQ117_RS18800
• Protein ID: WP_000365807.1
• Coordinates: 3902207..3903127 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LQ117_RS18795
• Protein ID: WP_001295795.1
• Coordinates: 3901438..3902220 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQ117_RS18790 (3898056)	3898056..3901154	-	3099	WP_000673070.1	type I restriction endonuclease	-
LQ117_RS18795 (3901438)	3901438..3902220	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
LQ117_RS18800 (3902207)	3902207..3903127	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQ117_RS18805 (3903292)	3903292..3904068	-	777	WP_000171155.1	site-specific integrase	-
LQ117_RS18810 (3904276)	3904276..3904611	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
LQ117_RS18815 (3904838)	3904838..3904996	-	159	Protein_3677	integrase	-
LQ117_RS18820 (3905045)	3905045..3905230	+	186	WP_000146240.1	hypothetical protein	-
LQ117_RS18825 (3905445)	3905445..3906059	+	615	WP_001019923.1	YagU family protein	-
LQ117_RS18830 (3906130)	3906130..3906296	+	167	Protein_3680	tail fiber assembly protein	-
LQ117_RS18835 (3906308)	3906308..3906637	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
LQ117_RS18840 (3906944)	3906944..3907654	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	3895188..3943343	48155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T295534 WP_000365807.1 NZ_OW848785:3902207-3903127 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT295534 WP_001295795.1 NZ_OW848785:3901438-3902220 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0