Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3365901..3366496 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag LQ117_RS16185 Protein ID WP_000239579.1
Coordinates 3366146..3366496 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LQ117_RS16180 Protein ID WP_001223208.1
Coordinates 3365901..3366152 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS16170 (3361566) 3361566..3365345 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
LQ117_RS16175 (3365348) 3365348..3365689 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LQ117_RS16180 (3365901) 3365901..3366152 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LQ117_RS16185 (3366146) 3366146..3366496 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
LQ117_RS16190 (3366576) 3366576..3367106 - 531 WP_000055075.1 inorganic diphosphatase -
LQ117_RS16195 (3367416) 3367416..3368372 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LQ117_RS16200 (3368512) 3368512..3370014 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
LQ117_RS16205 (3370028) 3370028..3371050 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T295530 WP_000239579.1 NZ_OW848785:3366146-3366496 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT295530 WP_001223208.1 NZ_OW848785:3365901-3366152 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References