Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2383439..2384239 Replicon chromosome
Accession NZ_OW848785
Organism Escherichia coli isolate 131

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag LQ117_RS11565 Protein ID WP_000342452.1
Coordinates 2383439..2383966 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag LQ117_RS11570 Protein ID WP_001277107.1
Coordinates 2383973..2384239 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ117_RS11540 (2378515) 2378515..2379282 - 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LQ117_RS11545 (2379279) 2379279..2380556 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
LQ117_RS11550 (2380553) 2380553..2381479 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LQ117_RS11555 (2381527) 2381527..2382636 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LQ117_RS11560 (2383059) 2383059..2383442 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
LQ117_RS11565 (2383439) 2383439..2383966 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
LQ117_RS11570 (2383973) 2383973..2384239 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
LQ117_RS11575 (2384388) 2384388..2385491 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LQ117_RS11580 (2385762) 2385762..2386616 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
LQ117_RS11585 (2386861) 2386861..2387919 - 1059 WP_001042013.1 permease-like cell division protein FtsX -
LQ117_RS11590 (2387912) 2387912..2388580 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T295526 WP_000342452.1 NZ_OW848785:c2383966-2383439 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT295526 WP_001277107.1 NZ_OW848785:c2384239-2383973 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References