Detailed information of TA system TA029552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 4717206..4718110
• Replicon: chromosome
• Accession: NC_021500
• Organism: Enterobacter sp. R4-368

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H650_RS22035
• Protein ID: WP_020457219.1
• Coordinates: 4717206..4717670 (-)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A4R0H5J7
• Locus tag: H650_RS22040
• Protein ID: WP_020457220.1
• Coordinates: 4717667..4718110 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H650_RS22015	4712458..4712679	-	222	WP_007374119.1	cold shock-like protein CspD	-
H650_RS22020	4713008..4713328	+	321	WP_017456164.1	ATP-dependent Clp protease adapter ClpS	-
H650_RS22025	4713359..4715647	+	2289	WP_020457217.1	ATP-dependent Clp protease ATP-binding subunit ClpA	-
H650_RS22030	4715715..4717103	-	1389	WP_044489821.1	diguanylate cyclase	-
H650_RS22035	4717206..4717670	-	465	WP_020457219.1	RES domain-containing protein	Toxin
H650_RS22040	4717667..4718110	-	444	WP_020457220.1	DUF2384 domain-containing protein	Antitoxin
H650_RS22045	4718266..4718484	-	219	WP_001040187.1	translation initiation factor IF-1	-
H650_RS22050	4718774..4719475	-	702	WP_020457221.1	leucyl/phenylalanyl-tRNA--protein transferase	-
H650_RS22055	4719582..4721309	-	1728	WP_020457222.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-
H650_RS22060	4721310..4723076	-	1767	WP_020457223.1	cysteine/glutathione ABC transporter permease/ATP-binding protein CydD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-146)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (29-90)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17212.76 Da
• Isoelectric Point: 6.4855

>T29552 WP_020457219.1 NC_021500:c4717670-4717206 [Enterobacter sp. R4-368]
VIFYRLVTRRYASEAWTGSGANLYGGRWNHKGHPAVYVASSVSLAALEMLVHMHSDAVMNQYGLFSIEIPDKEIEYLDKQ
WLPPDWQENPAPLSTMDLGTAWLEANSAVALVLPSCVVPLENNAILNPNHPAFNKLLKTVKALPFFFDPRLAHP

Nucleotide

• Length: 465 bp

>T29552 NC_021500:c4717670-4717206 [Enterobacter sp. R4-368]
GTGATCTTTTATCGACTGGTAACGCGCCGCTACGCCAGCGAAGCCTGGACAGGCAGCGGTGCAAATCTTTATGGCGGTCG
CTGGAATCACAAAGGTCACCCGGCGGTTTACGTCGCCTCATCCGTTTCGCTTGCCGCACTCGAAATGCTGGTGCATATGC
ACAGTGACGCGGTTATGAACCAGTATGGACTGTTCAGTATTGAGATCCCTGACAAGGAGATTGAATATCTGGATAAGCAA
TGGTTACCGCCAGACTGGCAGGAAAACCCGGCGCCGCTTTCGACCATGGATTTAGGTACCGCCTGGCTGGAAGCCAACAG
CGCCGTCGCGCTGGTGCTGCCGTCATGCGTTGTTCCGCTTGAGAATAATGCAATTCTGAACCCGAATCACCCCGCTTTTA
ATAAGCTGTTAAAAACCGTAAAAGCGCTTCCTTTCTTTTTTGATCCACGCCTGGCACACCCGTAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16421.84 Da
• Isoelectric Point: 8.8231

>AT29552 WP_020457220.1 NC_021500:c4718110-4717667 [Enterobacter sp. R4-368]
MRTWSPDQKPAENALWRFAGFPANRGLKLVQMLNEGLPVSILDNIHEWTEMSRSDILRVTGINERNVARRKSAGRTLTPE
ESERIARLVRVVDAAVQFFGSKKMAWDWLETPVRGLGNVAPISLIATESGALEVTDLLGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT29552 NC_021500:c4718110-4717667 [Enterobacter sp. R4-368]
ATGAGAACCTGGAGCCCGGATCAAAAACCAGCCGAAAATGCACTCTGGCGCTTTGCCGGTTTCCCCGCCAACAGAGGACT
AAAACTCGTTCAGATGTTGAACGAAGGCTTGCCAGTCAGCATTCTCGACAATATTCATGAATGGACAGAAATGTCCCGCT
CCGACATCCTGCGCGTCACGGGTATCAATGAACGCAATGTTGCGCGTCGCAAAAGCGCCGGCCGTACACTCACACCGGAA
GAAAGTGAGCGTATTGCGCGTTTAGTAAGGGTTGTTGATGCTGCGGTACAGTTTTTCGGTAGCAAAAAGATGGCGTGGGA
CTGGCTGGAAACCCCCGTTCGCGGCCTTGGCAATGTGGCGCCAATTTCGCTGATTGCCACTGAAAGTGGCGCGCTGGAGG
TGACCGACCTGCTCGGCAGGCTGGAACACGGAGTGTTTGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4R0H5J7